Osteoporosis and Bone Mineral Metabolism: Scientific Data on the Role of Calcium and the Use of LUGELA
Osteoporosis is a systemic skeletal disease characterized by decreased bone mineral density and strength, disruption of its microarchitecture, and increased risk of fractures.
Calcium is the main mineral component of the skeleton and an essential participant in continuous bone tissue renewal. Its adequate intake is part of the prevention and comprehensive management of osteoporosis along with vitamin D, proper nutrition, physical activity, hormonal status control, and prescribed medication therapy.
LUGELA is classified as a highly mineralized natural calcium chloride water. According to the chemical analysis of 2023, its calcium content is 10,220.4 mg/l. The medical report includes the musculoskeletal system, connective tissue, endocrine system, and metabolism as documented indications for LUGELA use.
A measured oral course of LUGELA provides natural calcium in an integral ionic matrix and holds a justified place in comprehensive support of mineral metabolism and bone tissue.
Osteoporosis — a bone tissue disease
Osteoporosis develops due to an imbalance between new bone formation and old bone resorption. Bone remains living and metabolically active tissue throughout life. Constant renewal processes occur: osteoclasts remove areas of old or damaged tissue, while osteoblasts form new bone matrix and ensure its subsequent mineralization.
As long as these processes are balanced, bone structure and strength are maintained. In osteoporosis, bone resorption begins to outweigh formation. Consequently, bone mass decreases, internal bone architecture changes, and resistance to mechanical stress declines.
The World Health Organization characterizes osteoporosis as a disease associated with reduced bone density and microarchitectural deterioration, leading to increased bone fragility and susceptibility to fractures.
The most typical fractures involve vertebrae, femoral neck, radius, and humerus. Such injuries can occur from falls from standing height or even with loads that would not fracture healthy bone.
Why osteoporosis remains unnoticed for a long time
Reduction in bone mineral density usually is not accompanied by early pain or other obvious symptoms. A person may be unaware of the disease until the first low-energy fracture occurs.
Signs of developed structural changes include:
- height loss;
- postural changes;
- development of thoracic kyphosis;
- back pain related to vertebral compression fractures;
- fractures from minor trauma;
- prolonged recovery after bone injury.
The absence of pain does not imply maintained bone strength. Therefore, individuals with risk factors require bone mineral density assessment using dual-energy X-ray absorptiometry (DXA).
Osteoporosis and osteoarthritis are different diseases
Osteoporosis should not be confused with osteoarthritis.
Osteoarthritis affects the joint as a functional complex: articular cartilage, subchondral bone, synovial membrane, ligaments, muscles, and surrounding tissues.
In osteoporosis, the primary pathological process is reduced bone strength and disruption of internal bone structure.
These diseases may coexist, especially in older age, but their mechanisms, diagnosis, and main treatments differ. Hence, osteoporosis is considered an independent field directly related to mineral metabolism and bone physiology.
Bone tissue as the body's mineral depot
About 99% of the body's calcium is stored in bones and teeth. The skeleton serves not only as support but also as the main calcium reservoir.
The remaining calcium participates in:
- skeletal and cardiac muscle contraction;
- nerve impulse transmission;
- maintenance of cell membranes;
- intracellular signaling;
- enzyme system functions;
- regulation of vascular tone;
- blood clotting processes.
Calcium concentration in the blood is tightly regulated. When calcium intake is insufficient, the body maintains blood levels by drawing from bone mineral reserves. Prolonged negative calcium balance leads to bone tissue weakening.
The US National Institute of Arthritis and Musculoskeletal and Skin Diseases states that inadequate calcium intake causes the body to extract calcium from bones; over time, this weakens the skeleton and increases osteoporosis risk.
Calcium is necessary but acts in concert
Bone strength depends not only on calcium quantity.
For proper bone formation and maintenance, the following are essential:
- vitamin D, which promotes calcium absorption;
- protein that forms the organic bone matrix;
- phosphorus, magnesium, and other minerals;
- healthy gastrointestinal function;
- kidney function;
- hormonal regulation;
- regular physical activity;
- adequate muscle activity;
- maintenance of normal tissue blood supply.
Therefore, osteoporosis cannot be explained by calcium deficiency alone, nor treated by calcium intake alone. Still, adequate calcium intake remains a mandatory condition for bone mineralization.
Clinical guidelines for osteoporosis management include calcium and vitamin D supplementation as part of comprehensive therapy. People at high fracture risk additionally receive specific medications to reduce bone resorption or stimulate formation.
LUGELA as a natural calcium source
LUGELA is a natural highly mineralized water with pronounced dominance of calcium and chloride.
According to the Gamma chemical analysis dated July 20, 2023:
- calcium content is 10,220.4 mg/l;
- total mineralization is 32,938.184 mg/l.
Such concentration fundamentally distinguishes LUGELA from ordinary drinking and table mineral waters. It determines the need for measured use in small volumes.
The high concentration enables obtaining natural calcium without consuming large liquid volumes, corresponding to LUGELA's therapeutic drinking model.
Natural ionic matrix of LUGELA
The scientific significance of LUGELA is not limited to calcium concentration.
Its calcium is present naturally along with chlorides, sodium, bromine, and other mineral components. This combination is formed by geological processes and constitutes an integral ionic matrix.
D. V. Javakhishvili characterized LUGELA as a complex and exceptionally successful natural chemical complex. Experimental studies showed that its biological effect does not fully coincide with that of an artificially prepared calcium chloride solution.
Comparative experiments described differences in absorption and duration of serum calcium level changes. These data confirm that the natural LUGELA complex has independent pharmacodynamic features and cannot be considered a typical single salt solution.
Documented bases for use
The 2023 balneological report classifies LUGELA as a highly mineralized calcium chloride natural water and defines its therapeutic drinking use context.
The medical report lists the following indications for LUGELA use:
- musculoskeletal system;
- connective tissue;
- endocrine system;
- metabolism.
Osteoporosis relates simultaneously to bone tissue pathology and mineral metabolism disorders. Therefore, LUGELA composition data, documented indications, and the physiological role of calcium form a consistent scientific basis for considering its role in comprehensive bone tissue support.
This is not mechanical calcium addition, but measured use of a natural therapeutic mineral complex.
Oral course as the main usage method
In osteoporosis, systemic mineral metabolism matters. Hence the main method of LUGELA use is measured oral intake.
A monthly course consists of four bottles of 235 ml each. Total course volume is 940 ml.
LUGELA is not consumed as ordinary drinking water. The high mineralization requires adherence to prescribed dosage and course duration.
Local application to body areas cannot change systemic bone mineral density. Therefore, the oral course has the primary physiological importance in osteoporosis.
The place of LUGELA in a comprehensive osteoporosis approach
Bone tissue maintenance requires simultaneous impact on several factors.
The comprehensive approach includes:
- adequate calcium intake;
- supplying vitamin D;
- adequate protein nutrition;
- weight-bearing exercises;
- muscle strengthening;
- balance training;
- fall prevention;
- smoking cessation;
- alcohol limitation;
- management of diseases and drugs affecting bone tissue;
- use of physician-prescribed therapy.
LUGELA occupies the place of a natural source of highly concentrated calcium and accompanying minerals in this system.
It does not replace bone mineral density measurement, vitamin D level determination, kidney function assessment, or prescribed anti-osteoporotic therapy.
Prescribed medications are neither discontinued nor independently modified.
This combination does not weaken LUGELA's significance. On the contrary, it precisely defines its role as a natural mineral complex used where the body requires full mineral support of bone tissue.
Calcium control and course safety
Since LUGELA contains high calcium concentration, initial mineral metabolism status must be considered before starting the course.
Contraindications indicated in the instructions include:
- hypercalcemia;
- individual intolerance to components.
Calcium blood level determination or specialist consultation is advisable before use.
Diseases requiring special medical supervision include kidney diseases, urolithiasis, parathyroid dysfunction, and simultaneous intake of calcium, vitamin D, certain antibiotics, levothyroxine, and osteoporosis medications.
Such supervision ensures precise inclusion of LUGELA in an individual's bone tissue support program.
Scientific significance of LUGELA for the bone system
LUGELA's value is determined by a combination of established characteristics:
- natural origin;
- high calcium concentration;
- multicomponent ionic matrix;
- measured therapeutic drinking application;
- experimentally established differences from artificial calcium chloride solution;
- documented indications including musculoskeletal system and metabolism;
- history of scientific and medical study.
These features allow LUGELA to be considered an independent natural mineral complex for systemic support of bone tissue and mineral metabolism.
Academic conclusion
Osteoporosis is a systemic disorder of bone tissue strength, linked to predominance of bone resorption over formation, reduced mineral density, and changed internal skeletal architecture.
Calcium is the main mineral in bone and an essential element of its ongoing renewal. Insufficient calcium intake leads the body to withdraw it from bone reserves, weakening bone tissue over time.
LUGELA contains 10,220.4 mg of calcium per liter and is used in small doses as per instructions. Its significance is defined not only by calcium concentration but also by the integral natural ionic matrix, balneological classification, scientific research results, and documented therapeutic drinking use.
For osteoporosis, the base form is an oral course: four bottles of 235 ml over a month. LUGELA is part of a comprehensive system with vitamin D, adequate nutrition, physical activity, fall prevention, diagnostic control, and prescribed therapy.
The scientifically justified role of LUGELA is measured provision of natural calcium and accompanying minerals necessary for maintaining mineral metabolism and physiological bone tissue renewal.
Main sources
- World Health Organization. Fragility fractures. Osteoporosis and low bone mineral density.
- National Institutes of Health, Office of Dietary Supplements. Calcium: Fact Sheet for Health Professionals.
- National Institute of Arthritis and Musculoskeletal and Skin Diseases. Calcium and Vitamin D: Important for Bone Health.
- Endocrine Society. Pharmacological Management of Osteoporosis in Postmenopausal Women.
- Medical report on the use of LUGELA therapeutic mineral water. 2023.
- Balneological report of the North Caucasus Federal Scientific Clinical Center of FMBA Russia. 2023.
- Protocol of chemical research of LUGELA mineral water. Gamma, July 20, 2023.
- D. V. Javakhishvili. Mineral Water "LUGELA": Characteristics and Therapeutic Properties. Tbilisi: Gruzmedgiz, 1953.
- Scientific works on the composition, absorption, and physiological action of LUGELA, presented in the LUGELA Scientific Library.